{"id":3040,"date":"2018-03-06T09:50:12","date_gmt":"2018-03-06T09:50:12","guid":{"rendered":"http:\/\/35.198.183.193\/?p=3040"},"modified":"2019-11-14T08:37:06","modified_gmt":"2019-11-14T08:37:06","slug":"whole-genome-sequencing-analysis-of-hereditary-breast-cancer","status":"publish","type":"post","link":"http:\/\/escience.sdu.dk\/index.php\/2018\/03\/06\/whole-genome-sequencing-analysis-of-hereditary-breast-cancer\/","title":{"rendered":"Whole Genome Sequencing Analysis of Hereditary Breast Cancer"},"content":{"rendered":"<p>Principal Investigator: <a href=\"http:\/\/findresearcher.sdu.dk\/portal\/en\/persons\/mads-thomassen(428f2151-f2aa-4a5e-bdee-4184c0586467).html\"> Mads Thomassen<\/a><\/p>\n<p>Faculty of Health Science &#8211; Department of Clinical Research &#8211; Human Genetics &#8211; SDU<\/p>\n<p><!--more--><\/p>\n<p>Breast cancer is the most common cancer among women. Up to 10% of all cases are inherited. Since breast cancer is associated with high mortality patients with a strong family history of breast\/ovarian cancer are referred to screening of the high-risk genes BRCA1 and BRCA2. In families where a mutation is identified, half of the daughters of a mutation carrier will not carry it and they can be spared prophylactic mastectomy and oophorectomy. Patients with BRCA1\/2 mutations have been shown to respond better to certain types of chemotherapy and a new targeted treatment, PARP inhibitors. A major problem in clinical managing is that mutations in BRCA1\/2 are only identified in app. 10% of referred families hampering counseling and treatment.<\/p>\n<p>We will seek to improve treatment and counseling of hereditary breast cancer by identifying molecular subtypes and the missing causal genetic factors for non-BRCA1\/2 familial breast cancers.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Principal Investigator: Mads Thomassen Faculty of Health Science &#8211; Department of Clinical Research &#8211; Human Genetics &#8211; SDU<\/p>\n","protected":false},"author":1,"featured_media":3897,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[5],"tags":[164,161,165,162,163],"_links":{"self":[{"href":"http:\/\/escience.sdu.dk\/index.php\/wp-json\/wp\/v2\/posts\/3040"}],"collection":[{"href":"http:\/\/escience.sdu.dk\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/escience.sdu.dk\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/escience.sdu.dk\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/escience.sdu.dk\/index.php\/wp-json\/wp\/v2\/comments?post=3040"}],"version-history":[{"count":3,"href":"http:\/\/escience.sdu.dk\/index.php\/wp-json\/wp\/v2\/posts\/3040\/revisions"}],"predecessor-version":[{"id":5006,"href":"http:\/\/escience.sdu.dk\/index.php\/wp-json\/wp\/v2\/posts\/3040\/revisions\/5006"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/escience.sdu.dk\/index.php\/wp-json\/wp\/v2\/media\/3897"}],"wp:attachment":[{"href":"http:\/\/escience.sdu.dk\/index.php\/wp-json\/wp\/v2\/media?parent=3040"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/escience.sdu.dk\/index.php\/wp-json\/wp\/v2\/categories?post=3040"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/escience.sdu.dk\/index.php\/wp-json\/wp\/v2\/tags?post=3040"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}