Principal Investigator: Qihua Tan

Faculty of Health Science – Epidemiology, Biostatistics and Biodemography – Human Genetics – SDU

Body mass index is an important indicator for determining obesity, which is highly correlated with cardiometabolic problem like coronary heart disease. It is contributed form multiple genetic and epigenetic factors. In this study, we focus on DNA methylation study and use twins discordant for BMI to control the genetic factors. Our results could benefit the public in the aspects of improve life quality and drug development. We have collected 30 twin pairs and measure their methylation level using reduced presentation bisulfite sequencing (RRBS) technology. RRBS is based on sequencing technology and it is a relatively new. The pipeline for processing such type of data is rather complex. Millions of reads need to be processed and mapped onto reference human genome, and the process need large amount of computational power.